rum1 — Schizosaccharomyces pombe 972h-

Summary

SPBC32F12.09 (rum1) on chromosome 2 of Schizosaccharomyces pombe 972h- encodes a cyclin-dependent protein kinase inhibitor. The Rum1 protein localises to the nucleus and is associated with negative regulation of mitotic cell cycle, negative regulation of G1/S transition of mitotic cell cycle, and negative regulation of mitotic DNA replication initiation. It is linked to mitotic G1 cell size control checkpoint, cell differentiation, sexual reproduction, and response to nutrient. The gene product is also associated with nuclear export, mitotic exit, and both G1 and G2 phases of the cell cycle. Additionally, rum1 is associated with upregulation of proteasomal ubiquitin-dependent protein catabolic process and traversing the Start control point of the mitotic cell cycle.