IMP2 — Schizosaccharomyces pombe 972h-

Summary

SPBC336.13C (IMP2, SpIMP2) on chromosome 2 of Schizosaccharomyces pombe encodes a peptidase belonging to the S26A signal peptidase family, with serine-type metalloendopeptidase activity (EC 3.4.21.-). The gene is associated with mitochondrial inner membrane peptidase complex localization and mitochondrial protein processing, as well as membrane tubulation, contractile ring contraction, abscission, vacuole fusion, cytokinesis, cell division, cell cycle progression, and morphogenesis. It is linked to numerous phenotypes including altered vegetative growth, decreased respiratory growth, increased replicative lifespan, decreased chronological lifespan, altered stress resistance (heat, oxidative, desiccation, starvation), abnormal vacuolar morphology, decreased biofilm formation, altered carbon and nitrogen source utilization, and changes in chemical compound accumulation and excretion. The gene is also associated with cell death and hypersensitivity.