CPCC — Schizosaccharomyces pombe 972h-

Summary

SPBC36B7.09 (symbol CPCC, also known as GCN2) on chromosome 2 of Schizosaccharomyces pombe encodes a protein serine/threonine kinase with eukaryotic translation initiation factor 2alpha kinase activity, histone H2BS14 kinase activity, MEKK activity, and phospholipid, tRNA, and ATP binding. The gene is associated with downregulation of translation initiation in response to stress, response to amino acid starvation and UV, G1/G0 transition, negative regulation of sterol import, positive regulation of autophagy, and regulation of mitotic actomyosin contractile ring assembly. It localizes to the Mcs4 RR-MAPKKK complex, meiotic spindle pole, septin ring, and spindle pole body. Phenotypic associations include altered cell cycle progression, increased virulence, abnormal spore germination, increased anaerobic growth, and increased freeze-thaw resistance. Related genes in other species link the family to oxidative stress response.