AMYC — Schizosaccharomyces pombe 972h-

Summary

SPBC3F6.05 (symbol AMYC, also known as rga1 or LRG1) on chromosome 2 of Schizosaccharomyces pombe encodes a Rho GTPase-activating protein (RhoGAP) with a Znf_LIM domain that binds small GTPases and metal ions. The gene is associated with positive regulation of establishment of bipolar cell polarity, regulation of actin cable assembly and actin cytoskeleton organization, regulation of cell wall organization or biogenesis, negative regulation of cell integrity MAPK cascade, and cell morphogenesis. Its product localizes to the cell cortex, cell tips, division septum, and medial ring. Phenotypic associations include abnormal bipolar budding pattern, cell fusion defects, delayed nuclear fusion during mating, decreased adhesion, abnormal shmoo formation, and abnormal pseudohyphal growth. Studies of related genes in other species link the family to acid sensitivity and interactions with CDC42 and signaling pathways.