stn1 — Schizosaccharomyces pombe 972h-

Summary

SPBC409.12C (stn1) in Schizosaccharomyces pombe 972h- encodes a telomeric ssDNA-binding protein that is a component of the telomere cap complex. The product contains an Stn1_N domain and an OB-fold nucleic-acid-binding domain, and it binds telomeric repeats. The gene is associated with telomere maintenance, telomere capping, and telomere localization, as well as with DNA replication, DNA repair, homologous recombination, and cell cycle modulation. It has also been connected to sumoylation, post-translational modification, and homeostasis. The protein localizes to the nucleus, specifically to the telomeric repeat region and the telomeric region of chromosomes. Related genes in other species link the family to the CST complex.