pxl1 — Schizosaccharomyces pombe 972h-

Summary

SPBC4F6.12 (pxl1) on chromosome 2 of Schizosaccharomyces pombe 972h- encodes a LIM domain-containing protein with PEP family features, possessing F-BAR domain binding, Rho GDP-dissociation inhibitor activity, and transcriptional co-regulator functions. The gene is associated with cytokinesis, including cleavage furrow formation, actomyosin contractile ring organization and assembly, and mitotic exit. It is linked to the septation initiation network (SIN), actin polymerization, cytoskeleton organization, and glucan anabolism. Additional associations include cell cycle regulation, mitosis, anaphase, cell division, and cell death. The protein localizes to the actomyosin contractile ring (intermediate layer), medial ring, nucleus, Z disc, and cell division site. Related genes in other species encode LIM zinc-binding domain-containing proteins.