ARK1 — Schizosaccharomyces pombe 972h-

Summary

SPBC543.02C (ARK1, SpARK1) in Schizosaccharomyces pombe 972h- encodes a DnaJ homolog subfamily C member 7, a chaperone co-factor with a DnaJ domain and TPR repeats that binds misfolded proteins, Hsp70, and ATP, and activates ATPase activity. The gene is associated with centrosome duplication, chromosome segregation, kinetochore assembly, sister chromatid segregation, and telophase, as well as TORC2 signaling, microtubule shortening, mitochondrial outer membrane protein import, and galactose-specific flocculation. It localizes to the cytoplasm, ER, mitochondria, and protein aggregate centers. Phenotypic associations include delayed cell cycle progression in G2 phase, decreased cytokinesis, abnormal filamentous growth, increased polyploidy, and decreased resistance to chemicals. Related genes in other species are linked to cell membrane stability and protein content.