mik1 — Schizosaccharomyces pombe 972h-

Summary

The fission yeast gene mik1 (SPBC660.14) on chromosome 2 encodes a protein kinase with serine/threonine and tyrosine kinase activity, classified as EC 2.7.11.1, and exhibits non-membrane spanning protein tyrosine kinase, MAPKK, and cAMP-dependent protein kinase activities. It also binds microtubules and ATP. Mik1 is associated with the negative regulation of mitosis, including the G2/M transition of the meiotic cell cycle and the mitotic cytokinesis checkpoint, as well as the G1/S phase transition and DNA replication regulation. It is linked to cell cycle control checkpoints, the pheromone response MAPK cascade, the glucose-sensing PKA pathway, ascospore formation, embryogenesis, and microtubule destabilization. The protein localizes to the nucleoplasm, mitotic spindle pole body, septin ring, cellular bud neck, and interphase nodes. Studies of related genes in other species, such as wee1 and SWE1, connect this family to mitotic entry control.