HDA1 — Schizosaccharomyces pombe 972h-

Summary

SPBC800.03 (HDA1, also known as clr3) on chromosome 2 of Schizosaccharomyces pombe encodes a histone deacetylase with activity toward histones H3 and H4, including H3-K9, H3-K14, H4-K5, H4-K8, H4-K12, and H4-K16, and is classified as EC 3.5.1.98. The protein contains a histone deacetylase domain and an Arb2 domain. HDA1 is associated with heterochromatin assembly, including constitutive, island, and subtelomeric heterochromatin, as well as nucleosome organization, RNA surveillance, and regulation of phenotypic switching. It localizes to the HDA1 complex, HDAC complex, Rpd3S, SET3C, and euchromatin. Phenotypic associations include increased mating-type switching, abnormal pheromone production, increased sporulation rate, increased fermentative growth, increased freeze-thaw resistance, and absent meiosis. Related genes in other species link the family to the SHREC complex.