PHOD — Schizosaccharomyces pombe 972h-

Summary

SPBC8E4.01C (PHOD, pho84) on chromosome 2 of Schizosaccharomyces pombe 972h- encodes a phosphate permease belonging to the major facilitator superfamily (MFS) with transmembrane transporter activity for phosphate, glycerol-3-phosphate, glycerophosphodiester, selenite, manganese, and D-glucose. The gene is associated with phosphate ion homeostasis, polyphosphate metabolism, lncRNA transcription, and response to nutrient conditions. It localizes to the plasma membrane, vacuolar membrane, Golgi, and endoplasmic reticulum. Phenotypic associations include altered cell cycle progression, increased starvation and freeze-thaw resistance, absent biofilm formation and mitophagy, abnormal vacuolar distribution, and increased respiratory metabolism. Studies of related genes in other species link the family to phosphate content, sodium content, and calcium sensitivity.