nbr1 — Schizosaccharomyces pombe 972h-

Summary

SPBP35G2.11C (nbr1) on chromosome 2 of Schizosaccharomyces pombe 972h- encodes a protein with a central N_BRCA1 domain, ZZ-type zinc fingers, and an Ig-like fold, and is annotated with cargo receptor activity and zinc binding. The gene is associated with autophagy, macroautophagy, microautophagy, ER-phagy, and ribophagy, as well as cargo selection, extracellular vesicle assembly, fatty acid oxidation, heme anabolism, translation initiation, memory, and cell cycle processes. Its product localizes to multivesicular bodies, the fungal-type vacuole lumen, and the Golgi complex. Studies of related genes in other species link the family to cytoplasm-to-vacuole targeting via the NVT pathway and to the NVT complex.