ASP1 — Schizosaccharomyces pombe 972h-

Summary

SPBPB8B6.05C (ASP1) in Schizosaccharomyces pombe 972h- encodes a probable L-asparaginase 4, a member of the asparaginase/glutaminase-like family with asparaginase activity (EC 3.5.1.1). The gene is associated with asparagine breakdown, cell quiescence, chromosome biorientation, mitochondrion distribution, polyphosphate metabolism, iron-sulfur cluster assembly, spindle assembly checkpoint, polar cell growth, cell morphogenesis, and regulation of gene expression. It has been linked to numerous phenotypes including abnormal flocculation, absent or altered biofilm formation, increased or decreased adhesion, abnormal colony shape, decreased invasive growth, increased vegetative growth rate, abnormal cell wall morphology, increased G1 phase duration, increased stress resistance, increased replicative lifespan, and increased innate thermotolerance. The product localizes to the periplasm, cytoplasm, and cell-bound compartments.