CHK1 — Schizosaccharomyces pombe 972h-

Summary

SPCC1259.13 (CHK1) on chromosome 3 of Schizosaccharomyces pombe encodes a serine/threonine protein kinase with protein kinase A activity, ATP binding, and identical protein binding. It is associated with DNA integrity checkpoint control, negative regulation of the cell cycle, response to ionizing radiation, UV, cisplatin, and hydroxyurea, single-strand break repair, chromosome separation, establishment of sister chromatid cohesion, and embryogenesis. The gene is linked to phenotypes including altered cell cycle progression rates in G1, G2, and metaphase, premature chromosome segregation, increased sporulation, decreased lifespan, and abnormal colony color. It is also associated with calcium sensitivity and oxidative stress response. Studies of related genes in other species link the family to loss of pathogenicity and protein content.