CDC20 — Schizosaccharomyces pombe 972h-

Summary

SPCC1620.04C, also known as CDC20 or mug55 in Schizosaccharomyces pombe 972h- on chromosome 3, encodes a WD40 repeat-containing protein of the Cdc20/Fizzy family and has ubiquitin ligase activator activity with APC binding activity. This gene is associated with the activation of meiosis, the meiosis I/II transition, mitotic anaphase, and the metaphase/anaphase transitions of both meiosis I and II. It is linked to mitotic spindle checkpoint function, MCC assembly, chromosome biorientation, and positive regulation of ascospore formation and the anaphase-promoting complex-dependent catabolic process. Phenotypic associations include premature or arrested cell cycle progression at multiple phases, altered meiosis timing, increased sporulation, decreased lifespan, and abnormal meiotic recombination. The protein localizes to the kinetochore, mitotic spindle, spindle pole body, nucleus, and cyclosome.