HAT2 — Schizosaccharomyces pombe 972h-

Summary

SPCC1672.10, also known as HAT2 or mis16 in Schizosaccharomyces pombe 972h- on chromosome 3, encodes a WD40-repeat protein belonging to the RBAP46/RBAP48/MSI1 family, with histone-binding and H3-H4 histone carrier activity. The gene is associated with centromere localization, kinetochore assembly, CENP-A-containing chromatin assembly, chromatin organization, telomeric silencing, and regulation of transcription by RNA polymerase II. It localizes to the nucleus, cytoplasm, kinetochore, centromere complex, and Rpd3S/Rpd3C(L) complexes. Phenotypically, HAT2 is linked to cell cycle progression defects including delayed or arrested S phase, G1/S and G2/M transitions, abnormal chromosome segregation, increased polyploidy, decreased growth, altered silencing, and reduced gamma ray resistance.