hrr1 — Schizosaccharomyces pombe 972h-

Summary

The fission yeast gene hrr1 (SPCC1739.03) on chromosome 3 encodes a protein with 5'-3' RNA helicase activity, DNA helicase activity, and ATP hydrolase activity, classified as EC 3.6.4.13. It belongs to the ZNFX1 and DNA2/NAM7-like helicase families. Hrr1 is associated with nonsense-mediated mRNA decay, RNA polymerase III transcription termination, tRNA processing, and RNAi-mediated heterochromatin assembly at centromeres. It is also linked to regulation of mRNA stability involved in response to oxidative stress, mitotic DNA replication lagging strand elongation, and chromatin silencing at centromeric and mating-type regions. The protein localizes to the DNA helicase A complex, RNA-directed RNA polymerase complex, nucleolar chromatin, and nuclear replication forks. Related genes in other species link the family to nonsense-mediated decay.