ARK1 — Schizosaccharomyces pombe 972h-

Summary

SPCC18.02, also known as ARK1 or SpARK1, encodes an uncharacterized MFS-type transporter with transmembrane transporter activity, belonging to the major facilitator superfamily (MFS) and localizing to the ER and membrane. In Schizosaccharomyces pombe, this gene is associated with regulation of chromosome segregation, centrosome duplication, kinetochore assembly, sister chromatid segregation, chromosome condensation, chromosome biorientation, and the spindle checkpoint, as well as TORC2 signaling, meiosis II, telophase, microtubule shortening, and flocculation. It is linked to phenotypes such as delayed cell cycle progression in G2 phase, arrested S phase, decreased cytokinesis, abnormal filamentous and pseudohyphal growth, decreased endocytosis, increased polyploidy, and altered pheromone sensitivity. Studies of related genes in other species connect the family to cell membrane stability and protein content.