DCL1 — Schizosaccharomyces pombe 972h-

Summary

SPCC188.13C, symbol DCL1 (dcr1) in Schizosaccharomyces pombe 972h- on chromosome 3, encodes a Dicer-like protein with RNase III, helicase, and dsRNA-binding domains. The gene product exhibits ribonuclease III, helicase, and dsDNA/dsRNA binding activities, and is annotated with euchromatin binding. DCL1 is associated with siRNA processing, RNAi-mediated heterochromatin assembly at centromeres, and posttranscriptional gene silencing. It is associated with antiviral response, regulation of cell cycle checkpoints, cell quiescence, and maintenance of G0 phase. The protein localizes to euchromatin, centric heterochromatin, the nuclear periphery, chromatin, cytoplasm, cytosol, and nucleus.