CCR4 — Schizosaccharomyces pombe 972h-

Summary

SPCC31H12.08C (CCR4) on chromosome 3 of Schizosaccharomyces pombe encodes a CCR4/Nocturnin family protein with endo/exonuclease/phosphatase and leucine-rich repeat domains. The enzyme has poly(A)-specific RNase and 3'-5' exoribonuclease activities. CCR4 is associated with mRNA poly(A) tail shortening, mRNA breakdown, heterochromatin organization, chromatin silencing, P body assembly, HOOD assembly, and response to UV, zinc, and UV-A. It localizes to the CCR4-NOT core complex, Paf1 complex, P body, cytoplasm, cytosol, and nucleus. The gene is linked to cell cycle progression including traversing the start control point, G2/M phase transition, and increased rate of passage through START. Phenotypic associations include increased sporulation, decreased polyploidy, increased virulence, abnormal pheromone sensitivity and cell cycle arrest, delayed fermentative metabolism and pexophagy, and decreased budding and cell death rate. Studies of related genes in other species connect the family to zinc sensitivity, phosphate content, and oxidative stress response.