CSH1 — Schizosaccharomyces pombe 972h-

Summary

SPCC4F11.04C (CSH1, imt2) on chromosome 3 of Schizosaccharomyces pombe encodes IPC mannosyltransferase 2, a glycosyltransferase-domain protein with inositol phosphorylceramide mannosyltransferase and mannosyltransferase activity. This gene is associated with MIPC biosynthetic process, chromatin silencing, constitutive heterochromatin assembly, PTGS, demethylation, nucleosome organization, anaphase, mitosis, morphogenesis, endocytosis, and methylation. The product localizes to the cis- and trans-Golgi network membrane, Golgi complex, and ER membrane. Phenotypic associations include decreased autophagy and pexophagy rates, absent flocculation and cell fusion, decreased hypoosmotic stress resistance and cell cycle progression, abnormal Golgi morphology, increased freeze-thaw resistance and fermentative growth, and delayed vacuolar transport and endocytosis. Related genes in other species are linked to acid sensitivity and oxidative stress response.