cut1 — Schizosaccharomyces pombe 972h-

Summary

SPCC5E4.04 (cut1) on chromosome 3 of Schizosaccharomyces pombe 972h- encodes a thiol endopeptidase (EC 3.4.22.49) with peptidase C50 and separin core domains. This gene is associated with numerous cell cycle processes, including mitotic and meiotic chromosome separation, sister chromatid cohesion maintenance, centromere separation, spindle elongation, and chromosome condensation. It is also linked to mitotic prophase, metaphase, anaphase, meiosis II, proteasome localization, cell size control, interphase, and nuclear movement. The encoded protein localizes to the Cut1-2 complex, mitotic spindle, spindle midzone, spindle pole body, cytoplasm, cytosol, and nucleus. Related genes in other species link the separase family to similar chromosome segregation functions.