CDC8 — Schizosaccharomyces pombe 972h-

Summary

SPCC70.07C (CDC8, tmp1) in Schizosaccharomyces pombe 972h- on chromosome 3 encodes a thymidylate kinase with dTMP kinase, dUMP kinase and nucleoside diphosphate kinase activities, and ATP binding, placing it in the P-loop NTPase superfamily. The gene is associated with dUDP, dTDP and dTTP anabolism, nucleotide metabolism, and DNA anabolism, as well as actin polymerization and depolymerization, cell polarization, maintenance of cell polarity, spindle assembly, nuclear division, vacuole fusion, spore germination, sexual reproduction, pheromone response, and interphase. It is linked to delayed chromosome segregation and mitotic cell cycle, mitotic arrest, decreased radiation and X-ray resistance, abnormal spindle and cytoskeleton morphology, increased autophagy and meiotic recombination, and decreased spore germination and budding index. The protein localises to the cytoplasm, cytosol and nucleus. Studies of related genes in other species link the family to abnormal S-phase progression and increased mitotic recombination.