CHA4 — Schizosaccharomyces pombe 972h-

Summary

SPCC757.04, also known as CHA4 or TEA1 in Schizosaccharomyces pombe 972h- on chromosome 3, encodes an uncharacterized transcriptional regulatory protein containing a Zn2Cys6 DNA-binding domain. The gene product exhibits sequence-specific DNA binding and RNA polymerase II transcription factor activity. CHA4 is associated with monopolar cell growth, microtubule dynamics and stabilization, actin depolymerization, cell migration, spore wall assembly, nitrogen utilization, and the DNA replication checkpoint. It localizes to the nucleus, nucleolus, chromatin, and nuclear membrane. Phenotypic associations link CHA4 to cell cycle progression, particularly G1 and G2/M phase arrest, delayed meiosis, abnormal sporulation and spore germination, altered budding patterns, increased mitotic recombination, decreased respiratory metabolism, and abnormal nitrogen and carbon source utilization. Studies of related genes in other species connect the family to nucleolar morphology.