RGF1 — Schizosaccharomyces pombe 972h-

Summary

SPAC1006.06 (RGF1, also known as rgf2, ROM1, ROM2, SpROM1, SpROM2, SpRGF1) on chromosome 1 of Schizosaccharomyces pombe encodes a Rho-type guanine nucleotide exchange factor (GEF) containing DH, PH, CNH, and DEP domains. The protein binds phosphatidylinositol-4-phosphate and lipids, and exhibits GDS activity. RGF1 is associated with regulation of cytokinesis, mitotic division septum assembly, cell wall organization and beta-glucan biosynthesis, ascospore wall assembly, cell integrity MAPK cascade, bipolar cell growth, actin cortex stabilization, and abscission. It localizes to the actomyosin contractile ring, division septum, cell cortex, and spore wall. Phenotypic associations include altered cytokinesis, septum formation, cell cycle progression, thermotolerance, virulence, spore germination, and pheromone response. Related genes in other species link the family to cell wall integrity signaling and morphogenesis.