SMC2 — Schizosaccharomyces pombe 972h-

Summary

SPAC10F6.09C (psm3, also known as SMC2) in Schizosaccharomyces pombe encodes a structural maintenance of chromosomes (SMC) family protein with ATP hydrolase and DNA translocase activities, and binds double-stranded DNA, chromatin and ATP. The gene is associated with chromosome condensation, sister chromatid cohesion, chromatin looping, centromere separation, and meiotic processes including diplotene, prophase and homologous chromosome orientation. It localises to the mitotic and meiotic cohesin complexes, the condensin complex, condensed chromosomes, kinetochores and euchromatin. Phenotypic associations link psm3 to abnormal cell cycle progression, premature metaphase-anaphase transition, delayed or absent chromosome segregation, increased gamma ray resistance, increased virulence, decreased polyploidy, and altered colony size, vegetative growth and sporulation efficiency. Studies of related genes in other species connect it to the cohesin complex.