HAT1 — Schizosaccharomyces pombe 972h-

Summary

SPAC139.06 (HAT1) on chromosome 1 of Schizosaccharomyces pombe encodes a type B histone acetyltransferase catalytic subunit, possessing histone H4K5, H4K8, and H4K12 acetyltransferase activities (EC 2.3.1.48) and histone and chromatin binding. The gene is associated with nitrogen utilization, negative regulation of pseudohyphal growth, phenotypic switching, mating, and telomeric silencing. It is linked to DNA repair and DNA repair-dependent chromatin remodeling, as well as cellular response to AOS. HAT1 localizes to the nucleus, cytoplasm, chromatin, telomeric regions, and the histone acetylase complex. Phenotypic associations include decreased exponential-phase growth, abnormal chronological lifespan, increased sporulation efficiency, decreased gamma ray resistance, and numerous cell cycle defects including delayed S phase, G2/M phase transition, and metaphase progression, as well as increased polyploidy and abnormal chromosome segregation. Studies of related genes in other species link the family to reduced virulence.