rad17 — Schizosaccharomyces pombe 972h-

Summary

SPAC14C4.13 (rad17) on chromosome 1 of Schizosaccharomyces pombe 972h- encodes a checkpoint protein with AAA+ ATPase and P-loop NTPase domains, and exhibits DNA clamp loader activity, ATP hydrolase activity, chromatin binding, and chromatin adaptor functions. The gene is associated with multiple cell cycle processes, including the mitotic G2 DNA damage checkpoint, DNA replication checkpoint, S-M checkpoint, and recombinational repair. It is linked to meiotic prophase I, the pachytene checkpoint, telomere capping, replication fork arrest, and responses to UV and UV-A radiation. The product localizes to the nucleus, chromatin, chromosome telomeric repeat regions, and sites of double-strand breaks. Related genes in other species are associated with Rad17-RFC localization.