ARK1 — Schizosaccharomyces pombe 972h-

Summary

SPAC1687.15 (ARK1, also known as gsk3) on chromosome 1 of Schizosaccharomyces pombe encodes a dual-specificity protein kinase with serine/threonine and tyrosine kinase activities, belonging to the GSK-3 family. This gene is associated with chromosome segregation, centrosome duplication, centromere localization, sister chromatid segregation, chromosome biorientation, condensation, and telophase. It is linked to stress-activated MAPK cascade signaling, TORC2 signaling, osmolarity sensing, galactose-specific flocculation, protein positioning, ubiquitin-mediated endocytosis, microtubule shortening, tube formation, and meiosis II. The protein localizes to the cytoplasm, cytosol, and nucleus. Phenotypic associations include delayed G2 phase cell cycle progression, decreased endocytosis, abnormal filamentous and pseudohyphal growth, decreased mating type switching, decreased pheromone sensitivity, increased polyploidy, and decreased necrotic cell death.