SPO11 — Schizosaccharomyces pombe 972h-

Summary

SPAC17A5.11, also known as SPO11 or rec12 in Schizosaccharomyces pombe 972h- on chromosome 1, encodes a protein with DNA topoisomerase type II activity (EC 5.6.2.2) that belongs to the Spo11/TopoVI_A family and contains a TOPRIM domain. This gene is associated with meiotic processes including DNA double-strand break formation and processing, meiotic prophase I, sister chromatid cohesion, chromosome segregation, homologous chromosome orientation in metaphase I, strand invasion, gene conversion, and the pachytene checkpoint. It is also linked to premeiotic DNA replication, meiotic S phase, meiosis II, nucleus organization, suppression of meiotic recombination, DNA deamination, steroidogenesis, and digestion. The protein localizes to the nucleus, nuclear chromosome, and sites of double-strand breaks. Related genes in other species link this family to meiosis-specific topoisomerase function.