BD — Schizosaccharomyces pombe 972h-

Summary

SPAC17H9.09C (SpBD) on chromosome 1 of Schizosaccharomyces pombe encodes a small GTPase of the Ras-type family, possessing GTP, GDP, CTP and UTP binding activities, GTPase activity and protein serine/threonine kinase activator activity. The gene is associated with Ras protein signal transduction, TORC2 signaling, response to glucose and metformin, regulation of conjugation with cellular fusion, karyogamy, cell-cell fusion, positive regulation of the pheromone response MAPK cascade, regulation of cytoskeleton organization, microtubule dynamics, protein farnesylation, and protein localization to the plasma membrane. It localizes to the plasma membrane, cytoplasm, nucleus, division septum, cell cortex of cell tip, mating projection actin fusion focus, and cortical dynamic polarity patch. Phenotypic associations include altered mating type switching, decreased vacuolar transport rate, absent bipolar budding, decreased redox state, absent osmotic and oxidative stress resistance, decreased rate of entry into G0, and increased recovery from pheromone-induced cell cycle arrest.