tsc2 — Schizosaccharomyces pombe 972h-

Summary

SPAC18B11.11, designated tsc2 in Schizosaccharomyces pombe 972h- on chromosome 1, encodes a protein containing a Tuberin_N domain and a Tuberin/Ral-act_asu domain, and exhibits GTPase-activating protein (GAP) activity. The gene is associated with negative regulation of TOR signaling and TORC1 signaling, as well as positive regulation of autophagy and negative regulation of G1/S transition of the mitotic cell cycle. It is linked to amino acid import, including upregulation of L-leucine and activation of L-arginine uptake, and to protein farnesylation. Associations extend to response to nutrient, regulation of cell growth, amino acid anabolism, arginine anabolism, meiosis, and mating. The encoded product localises to the TSC1-TSC2 complex, the cell division site, cytoplasm, cytosol, and nucleus.