chp1 — Schizosaccharomyces pombe 972h-

Summary

SPAC18G6.02C (chp1) in Schizosaccharomyces pombe 972h- encodes a chromodomain-containing protein that acts as a reader of histone H3K9me2/3 and binds ssRNA, histones, chromatin, and DNA. Chp1 is a core component of the RITS complex and is associated with RNAi-mediated heterochromatin assembly at centromeres, centromeric silencing, telomeric silencing, and silent mating-type cassette chromatin silencing. The gene is linked to heterochromatin organization, kinetochore assembly, RNA surveillance, anaphase, S phase, DNA replication, the TCA cycle, mating, and hypersensitivity. Chp1 localizes to heterochromatin islands, subtelomeric and centric heterochromatin, the mating-type region, the spindle pole body, and condensed centric chromosome regions.