CP1 — Schizosaccharomyces pombe 972h-

Summary

SPAC19G12.10C (CP1, also known as cpy1) in Schizosaccharomyces pombe 972h- on chromosome 1 encodes a serine carboxypeptidase (EC 3.4.16.5) belonging to the peptidase S10 and alpha/beta hydrolase families, with the protein product containing a PEP domain. The gene is associated with spindle localization, septum positioning, microtubule bundling and nucleation, mitotic spindle assembly, protein catabolic process in the vacuole, and cellular senescence. It is linked to cellular response to nitrogen starvation, zymogen activation, and phytochelatin anabolism. The protein localizes to the fungal-type vacuole and its lumen. CP1 is associated with altered cell death, abnormal autophagy and mitophagy, increased aneuploidy, abnormal nuclear fusion during mating, and changes in prion inheritance and lifespan. Related genes in other species link the family to apoplastic effector functions.