RTS1 — Schizosaccharomyces pombe 972h-

Summary

SPAC1F5.11C (RTS1, tra2) on chromosome 1 of Schizosaccharomyces pombe encodes a protein with protein serine/threonine kinase activity, ATP binding, and pre-rRNA binding, and belongs to the PI3/4-kinase catalytic domain superfamily. It is associated with TORC2 signaling, DNA damage response signal transduction, replication fork arrest, DNA replication termination, and positive regulation of cytoplasmic translation and ribosomal protein gene transcription. The gene is linked to cell cycle progression, including G1/S transition and G2/M phase transition, as well as negative regulation of the mitotic-to-meiotic cell cycle switch and of rDNA heterochromatin formation. Phenotypic associations include decreased autophagy and pexophagy rates, increased mating-type switching, absent X-ray resistance, and abnormal sporulation efficiency. The protein localizes to the TOR complex, nucleolar chromatin, and the TIP60 histone acetylase complex.