cdc15 — Schizosaccharomyces pombe 972h-

Summary

cdc15 (SPAC20G8.05C) in Schizosaccharomyces pombe 972h- on chromosome 1 encodes a protein with peptidase inhibitor activity, phosphatidylinositol-3-phosphate binding, cytoskeletal protein-membrane anchor activity, phosphatidylserine binding, phosphatidylinositol-4-phosphate binding, and phospholipid binding. It contains F-BAR, FCH, AH/BAR, and SH3 domains. This gene is associated with cleavage furrow formation, contractile ring contraction, abscission, actin nucleation, membrane bending and tubulation, ruffle assembly, establishment of bipolar cell polarity, cell cycle transitions including G1/G0 transition and spindle breakdown, cell motility, chemotaxis, and regulation of IL-1 production. The protein localizes to the actomyosin contractile ring, midsome, CAR, medial membrane band, endosome, cell tip, mating projection tip, and actin patch. Studies of related genes in other species link the family to cell division control.