RHO1 — Schizosaccharomyces pombe 972h-

Summary

SPAC20H4.11C, also known as RHO1 or rho5 in Schizosaccharomyces pombe, encodes a small GTPase of the Rho family with GTPase activity, GDP and GTP binding, protein serine/threonine kinase activator activity, and signaling adaptor activity. It is associated with cell wall beta-glucan and alpha-glucan biosynthesis, contractile ring contraction and regulation, cleavage furrow ingression, septum digestion and biogenesis, spore wall assembly, and positive regulation of formin-nucleated actin cable assembly. The protein localizes to the 1,3-beta-glucan synthase complex, growing cell tips, the cell cortex, and the internal side of the plasma membrane. Phenotypic associations include decreased septum formation, abnormal bipolar budding, absent cell fusion, decreased adhesion, increased shmoo formation rate, and altered endocytosis and protein transport. Studies of related genes in other species link the family to oxidative stress response, acid sensitivity, and loss of pathogenicity.