tsc1 — Schizosaccharomyces pombe 972h-

Summary

SPAC22F3.13 (tsc1) in Schizosaccharomyces pombe 972h- encodes a protein with a Hamartin domain and an ARM-type fold that exhibits GTPase-activating protein (GAP) activity. The gene is associated with negative regulation of TOR and TORC1 signaling, as well as positive regulation of L-methionine import and upregulation of L-leucine and L-arginine uptake. It is linked to amino acid import, protein farnesylation, negative regulation of the G1/S transition of the mitotic cell cycle, and regulation of cell growth. Additional associations include response to nutrient levels, cell cycle modulation, amino acid and arginine anabolism, meiosis, and mating. The product localizes to the TSC1-TSC2 complex and the cytoplasm.