CLP1 — Schizosaccharomyces pombe 972h-

Summary

SpCLP1 (SPAC22H10.05C) on chromosome 1 of Schizosaccharomyces pombe encodes a Clp1 family protein with ATP-dependent RNA kinase and polynucleotide 5'-hydroxy-kinase activities, and binds both RNA and ATP. The gene is associated with mRNA 3'-end processing, tRNA splicing, ciliogenesis, and numerous cell cycle processes including mitotic exit, spindle assembly checkpoint, chromosome biorientation, and sister chromatid cohesion. It localises to the nucleus, cytosol, and mRNA cleavage factor complexes. Phenotypic associations link SpCLP1 to abnormal RNA modification and accumulation, arrested vegetative growth, altered stress resistance (increased osmotic and heat tolerance, increased cold sensitivity), decreased sporulation efficiency, reduced telomere length, increased mutation frequency, and abnormal nuclear and nucleolar morphology. The gene also shows connections to carbon source utilisation, invasive growth, and colony sectoring.