RPB2 — Schizosaccharomyces pombe 972h-

Summary

RPB2 (SPAC23G3.01) on chromosome 1 of Schizosaccharomyces pombe encodes a protein with DNA-directed RNA polymerase activity, RNA-dependent RNA polymerase activity, ribonucleoside binding, DNA binding, RNA binding, and zinc binding. The protein belongs to the RNA polymerase Rpb2 domain family and is a core component of RNA polymerase I, II, and III complexes, localising to the nucleus, chromatin, and centric heterochromatin. RPB2 is associated with transcription elongation and initiation from Pol I and Pol III promoters, siRNA and snRNA transcription, RNAi-mediated heterochromatin assembly at centromeres, chromatin silencing, and nucleotide excision repair pathways. Phenotypic associations link the gene to cell cycle progression, meiosis, chromosome segregation, spore wall formation, and responses to radiation. RPB2 is also connected to altered fermentative and respiratory metabolism, decreased anaerobic growth, and increased aneuploidy.