HOG1 — Schizosaccharomyces pombe 972h-

Summary

SPAC24B11.06C (HOG1, sty1) on chromosome 1 of Schizosaccharomyces pombe encodes a mitogen-activated protein kinase (MAPK) of the p38/Sty1 family, possessing protein serine/threonine kinase activity and RNA polymerase II CTD heptapeptide repeat kinase activity. This gene is associated with the stress-activated protein kinase (SAPK) signaling pathway and responses to salt, hydrostatic pressure, methylglyoxal, and oxidative stress. It is linked to regulation of lipid storage, triglyceride and cholesterol homeostasis, glucose detection, and ferroptosis. The encoded protein localizes to the cytoplasm, nucleus, chromatin, stress granules, and mitochondrial envelope lumen. Phenotypic associations include decreased cell cycle progression rate, absent osmotic stress resistance, altered mating efficiency, increased acquired thermotolerance, and abnormal flocculation. Studies of related genes in other species link it to p38 cascade signaling, virulence, and stress responses.