FOR — Schizosaccharomyces pombe 972h-

Summary

SPAC24C9.12C, also known as FOR or shm1 in Schizosaccharomyces pombe 972h- on chromosome 1, encodes a serine hydroxymethyltransferase (SHMT) with glycine hydroxymethyltransferase activity and pyridoxal phosphate binding, classifying it as EC 2.1.2.1. The gene is associated with tetrahydrofolate metabolism and interconversion, pore formation, abscission, Golgi localization, actin nucleation, NPC assembly, nuclear transport, deubiquitination, heme anabolism, cell polarization, chromatin silencing, and the ERAD pathway. It localizes to the mitochondria, cytoplasm, cytosol, and fungal biofilm matrix. Phenotypic associations include arrested meiosis, decreased S-phase progression, absent respiratory metabolism, abnormal plasma membrane morphology, increased fermentative metabolism, decreased colony size, and abnormal cytokinesis. Studies of related genes in other species link the family to nutrient utilization and turgor pressure.