mei2 — Schizosaccharomyces pombe 972h-

Summary

SPAC27D7.03C (mei2) on chromosome 1 of Schizosaccharomyces pombe 972h- encodes a Mei2 protein containing RNA recognition motif (RRM) domains, with molecular functions including lncRNA binding, protein sequestering activity, poly(U) binding, and RNA binding. The gene is associated with numerous meiotic processes, including positive regulation of the meiotic cell cycle, entry into meiosis, meiotic S phase, prophase, second meiotic division, regulation of chromosome segregation, sister chromatid segregation, karyogamy, and syngamy, as well as negative regulation of conjugation with zygote. Additional associations include response to glucose, amino acid import, rRNA 2'-O-methylation, rRNA modification, protein splicing, exosome-mediated processes, vision, regulation of cell division, and calcium sensitivity. The protein localises to the nucleus, cytoplasm, cytosol, nuclear chromosome, and the Mei2 dot. Related genes in other species link it to the Tor2-Mei2-Ste11 complex.