MRN1 — Schizosaccharomyces pombe 972h-

Summary

SPAC2F7.11, also known as MRN1 or nrd1 in Schizosaccharomyces pombe 972h- on chromosome 1, encodes an RNA-binding protein containing Mrn1_RRM1 and RRM domains that binds poly(U) and mRNA. The gene is associated with mRNA stabilization and 3'-end processing, RNA processing, regulation of gene expression, and negative regulation of transcription by RNA polymerase II. It is linked to responses to glucose and heat, chromatin silencing, nuclear import and export, cytokinesis, sporulation, meiosis, mating, and meiotic cell cycle. Phenotypic associations include absent mating-type switching and sporulation, increased mutation frequency, decreased telomere length and gamma-ray resistance, abnormal cell cycle progression and nucleolar morphology, and altered carbon source utilization and vegetative growth. The protein localizes to the cytoplasm, cytosol, and stress granules.