tip1 — Schizosaccharomyces pombe 972h-

Summary

SPAC3C7.12 (tip1) in Schizosaccharomyces pombe 972h- encodes a CAP-Gly domain-containing protein that binds microtubule plus-ends. The gene product is associated with microtubule dynamics, including stabilization, assembly, and shortening, as well as microtubule-based transport and organization of the cytoplasmic microtubule cytoskeleton. Tip1 is linked to cell polarity maintenance, spindle elongation, mitotic spindle orientation, and cell cycle progression through G2 phase, M phase, metaphase, and interphase. It has been connected to the DNA replication checkpoint and spindle assembly checkpoint. The protein localizes to microtubule ends, including astral microtubules of the mitotic spindle, cortical and cytoplasmic microtubule plus-ends, the cell cortex, cell tips, and the cytosol.