CDC4 — Schizosaccharomyces pombe 972h-

Summary

SPAC4D7.03 (CDC4, pop2) on chromosome 1 of Schizosaccharomyces pombe encodes a protein with F-box and WD40-repeat domains that acts as a ubiquitin ligase substrate adaptor. It is associated with dynein complex and microtubule plus-end binding, as well as GTP binding. The gene is linked to negative regulation of mitotic DNA replication initiation, regulation of cell division, contractile ring assembly, microtubule organizing center organization, vesicle transport along microtubules, and SCF-dependent proteasomal ubiquitin-dependent protein breakdown. It localizes to the SCF complex, nuclear SCF complex, microtubule-associated complex, kinetochore, and nuclear envelope. Phenotypic associations include altered cell cycle progression through the G1/S phase transition, mating efficiency, chromosome segregation, sporulation, and germination rate. Studies of related genes in other species link the family to reduced virulence.