tsc2 — Schizosaccharomyces pombe 972h-

Summary

SPAC630.13C (tsc2) on chromosome 1 of Schizosaccharomyces pombe encodes a protein with a PEP domain and multiple tuberin-type domains, including a Rap/Ran-GAP domain, and exhibits GTPase-activating protein (GAP) activity. The gene is associated with the TSC1-TSC2 complex and localises to the cytoplasm, cytosol, nucleus and cell division site. It is linked to negative regulation of TOR and TORC1 signalling, positive regulation of autophagy, regulation of cell growth, and negative regulation of the G1/S transition. Additional associations include amino acid import, particularly leucine and arginine uptake, protein farnesylation, response to nutrient levels, and processes such as meiosis and mating. Related genes in other species connect the family to tuberin function and Rap-GAP domain-containing proteins.