DLH1 — Schizosaccharomyces pombe 972h-

Summary

SPAC644.14C, designated DLH1 (also known as rad51), on chromosome 1 of Schizosaccharomyces pombe 972h- encodes a recombinase with ATP hydrolase activity, ATP-dependent DNA damage sensor activity, and ATPase activity acting on DNA. The protein binds single- and double-stranded DNA, identical proteins, and the Sae3-Mei5 complex, and belongs to the RecA/Rad51 family of DNA recombination and repair proteins. DLH1 is associated with meiotic strand invasion, resolution of recombination intermediates, meiotic prophase I, meiotic chromosome organization, and response to ionizing radiation. It localizes to the nucleus, chromatin, condensed nuclear chromosome, centromere complex, and sites of double-strand breaks. Phenotypic associations include absent X-ray resistance, absent mitotic recombination, absent sporulation efficiency, abnormal spore germination, delayed chromosome segregation, and altered cell cycle progression through G1/S and metaphase-anaphase transitions.