BUB2 — Schizosaccharomyces pombe 972h-

Summary

SPAC6F6.08C, also known as BUB2 or cdc16 in Schizosaccharomyces pombe on chromosome 1, encodes a protein with a Rab-GAP TBC domain and GTPase-activating protein (GAP) activity, and it also binds calcium ions. This gene is associated with negative regulation of division septum assembly, the septation initiation network (SIN), spindle assembly checkpoint, spindle orientation and positioning, centromere separation, septin ring disassembly, and chromosome condensation. It localizes to the SIN/MEN two-component GAP complex, spindle pole bodies, the cell division site, and the cytoplasm. Phenotypically, BUB2 is linked to abnormal cell cycle progression, particularly in anaphase, premature metaphase-anaphase transition, increased sporulation, decreased lifespan, and altered mating efficiency. Studies of related genes in other species connect the family to mitotic checkpoint functions.