tpz1 — Schizosaccharomyces pombe 972h-

Summary

SPAC6F6.16C (tpz1) in Schizosaccharomyces pombe 972h- encodes a telomere-binding protein that belongs to the ACD and TPP1/Est3 domain families. The gene product is associated with telomere maintenance via telomerase, telomere capping, and telomere-telomerase complex assembly. It has been linked to telomeric and centromeric silencing, chromatin silencing, sumoylation, RNA splicing, DNA damage checkpoint, homologous recombination, cell cycle modulation, and chromosome division. The protein localises to the telomere cap complex, telomerase holoenzyme complex, and chromosome telomeric repeat region. Related genes in other species are also associated with the telosome.