rif1 — Schizosaccharomyces pombe 972h-

Summary

SPAC6F6.17 (rif1) on chromosome 1 of Schizosaccharomyces pombe 972h- encodes a Rif1 protein containing an N-terminal Rif1_N domain and an ARM-type fold. The product is a chromatin adaptor with G-DNA binding activity. Rif1 is associated with telomere organization, telomere 3'-end processing, and telomeric silencing, as well as telomere maintenance. It is linked to regulation of DNA replication, DNA replication initiation, and the DNA damage checkpoint. The protein is associated with cell cycle phases including G1, S, and M phase, and with anaphase, mitosis, and meiosis. Associations with homologous recombination, strand invasion, fHC assembly, and chromosome division have also been observed. Rif1 localizes to the chromosome telomeric repeat region, chromatin, nucleolus, and nucleus.